So in the app simulator, all the rotations for the hand bones are pointing towards the player head. They work correctly when they run on the actual device.
to repro you can just go to the hand tracking sample, and in HandVisualizer.cs just draw cubes instead of spheres and you'll see how they behave differently on device vs on the simulator (target device).
Unity Editor version: 2022.2.19
ML2 OS version: 1.2
MLSDK version: 1.2
Host OS: Windows